Chemical name : paroxetine
hydrochloride, (-)trans-3-[(1,3-benzodioxol-5-yloxy)
methyl]-4-(4-fluorophenyl) piperidine hydrochloride
C A S : 78246-49-8
Structural formula:
Discription : white or off-white crystalline
powder , odorless, tiny bitter . Easily soluble in methanol,
soluble in alcohol, little soluble in water.
Quality Standard : EP5
Application : Paroxetine is new antidepressant
and indicated for the treatment of various major depressive
disorder. The efficacy of paroxetine is to be linked
to potentiation of serotonergic activity in the central
nervous system resulting from competitive inhibition
of neuronal presynapse membrane reuptake of 5- hydroxylamine
and cause the accumulation of the latter in synaptic
cleft, help the impulsion transmission of 5-hydroxylamine
to nerve. The selective is higher than fluxetin, sertraline
and clomipramine. Paroxetine is not sedative actions.
Normal dosage has no affect on heart rate and blood
pressure. Paroxetine has very low affinity for cholinergic,
histamine or adrenergic receptors. Adverse event in
anti-cholin and cardiovascular is lower than tricyclic
antidepressant desipramine. It did not produce impairment
of intellectual function or psychomotor performance.
The acute and chronic treatment was unchanged specifically
in parameter of haematology, biochemistry and urogenital.
Package : 5kg/tin .
Storage : sealed , keep in room temperature.
Period of retest : three years temporary.
